Eosinophilia is associated with which disease?

• A. Gout
• B. Rheumatoid arthritis
• C. Peripheral vascular disease
• D. Osteoarthritis

Answer: (C)

Eosinophilia signals an eosinophil-driven process, most commonly seen with allergic reactions, parasitic infections, and certain eosinophilic vasculitides (for example, eosinophilic granulomatosis with polyangiitis). It is not a hallmark of degenerative or standard inflammatory joint diseases like gout, osteoarthritis, or the typical inflammatory arthritis. Peripheral vascular disease is a vascular condition tied to atherosclerosis and ischemia rather than eosinophil-dominated inflammation. So, when eosinophilia is present, you’d look for allergic, parasitic, or eosinophilic vasculitic processes rather than these common joint/vascular conditions. The listed options don’t fit the typical associations with eosinophilia.