In Von Willebrand disease, which laboratory findings are typically observed?

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Multiple Choice

In Von Willebrand disease, which laboratory findings are typically observed?

Explanation:
Von Willebrand disease affects both primary hemostasis and the intrinsic coagulation pathway. When vWF is reduced or dysfunctional, platelets have trouble adhering to damaged endothelium, which prolongs the bleeding time because the initial platelet plug forms more slowly. At the same time, vWF carries and stabilizes factor VIII; with less vWF, factor VIII falls, extending the intrinsic pathway and causing a prolonged aPTT. The PT/INR remains normal because the extrinsic pathway is not directly affected. Platelet count is typically normal. Therefore, the characteristic pattern is a prolonged bleeding time with a prolonged aPTT.

Von Willebrand disease affects both primary hemostasis and the intrinsic coagulation pathway. When vWF is reduced or dysfunctional, platelets have trouble adhering to damaged endothelium, which prolongs the bleeding time because the initial platelet plug forms more slowly. At the same time, vWF carries and stabilizes factor VIII; with less vWF, factor VIII falls, extending the intrinsic pathway and causing a prolonged aPTT. The PT/INR remains normal because the extrinsic pathway is not directly affected. Platelet count is typically normal. Therefore, the characteristic pattern is a prolonged bleeding time with a prolonged aPTT.

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