Lesch-Nyhan syndrome is associated with juvenile gout.

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Multiple Choice

Lesch-Nyhan syndrome is associated with juvenile gout.

Explanation:
This statement is true. Lesch-Nyhan syndrome results from deficiency of the HGPRT enzyme, which disrupts purine salvage. This leads to increased de novo purine synthesis and marked hyperuricemia from early life. The elevated uric acid can crystallize in joints and kidneys, so gout can appear in childhood or adolescence rather than being limited to adults. Therefore juvenile gout is a recognized association with this condition. It is a metabolic disorder related to purine metabolism, not unrelated, and its gout presentation is not restricted to adolescence only.

This statement is true. Lesch-Nyhan syndrome results from deficiency of the HGPRT enzyme, which disrupts purine salvage. This leads to increased de novo purine synthesis and marked hyperuricemia from early life. The elevated uric acid can crystallize in joints and kidneys, so gout can appear in childhood or adolescence rather than being limited to adults. Therefore juvenile gout is a recognized association with this condition. It is a metabolic disorder related to purine metabolism, not unrelated, and its gout presentation is not restricted to adolescence only.

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