Warfarin inhibits which coagulation pathway?

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Multiple Choice

Warfarin inhibits which coagulation pathway?

Explanation:
Warfarin works by inhibiting vitamin K–dependent gamma-carboxylation of several clotting factors, specifically II, VII, IX, and X. Of these, factor VII drives the extrinsic pathway, and it has the shortest half-life, so its levels fall first. That causes prolongation of the prothrombin time (PT), which reflects the extrinsic pathway. Fibrinolysis isn’t directly affected by warfarin, and while the common pathway is impacted as II and X decrease, the clinical lab sign most associated with warfarin effect is an elongated PT through the extrinsic pathway.

Warfarin works by inhibiting vitamin K–dependent gamma-carboxylation of several clotting factors, specifically II, VII, IX, and X. Of these, factor VII drives the extrinsic pathway, and it has the shortest half-life, so its levels fall first. That causes prolongation of the prothrombin time (PT), which reflects the extrinsic pathway. Fibrinolysis isn’t directly affected by warfarin, and while the common pathway is impacted as II and X decrease, the clinical lab sign most associated with warfarin effect is an elongated PT through the extrinsic pathway.

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